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  • Title: A new strategy for the synthesis of optically pure beta-fluoroalkyl beta-amino acid derivatives.
    Author: Fustero S, del Pozo C, Catalán S, Alemán J, Parra A, Marcos V, Ruano JL.
    Journal: Org Lett; 2009 Feb 05; 11(3):641-4. PubMed ID: 19128027.
    Abstract:
    The first general approach for the diastereoselective formation of a variety of optically pure anti-beta-fluoroalkyl beta-amino acid derivatives is described. The process relies on the stereocontrolled reaction, mediated by a remote sulfoxide, of fluorinated imines with sulfinylated benzyl carbanions, which are used as synthetic equivalents of chiral ester enolates.
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