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  • Title: Preliminary evaluation of pharmacological properties of some xanthone derivatives.
    Author: Marona H, Szkaradek N, Rapacz A, Filipek B, Dybała M, Siwek A, Cegła M, Szneler E.
    Journal: Bioorg Med Chem; 2009 Feb 01; 17(3):1345-52. PubMed ID: 19131251.
    Abstract:
    A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for alpha(1)- and beta(1)-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.
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