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  • Title: Response of cytosolic calcium to anoxia and cyanide in cultured glomus cells of newborn rabbit carotid body.
    Author: Sato M, Ikeda K, Yoshizaki K, Koyano H.
    Journal: Brain Res; 1991 Jun 14; 551(1-2):327-30. PubMed ID: 1913162.
    Abstract:
    Microscopic fluorometry was used to examine the effects of anoxia and cyanide (CN-) on cytosolic calcium [Ca2+]i of cultured carotid body (CB) glomus cells from newborn rabbits. Applications of high K+ and veratridine (VRT), a sodium channel activator, induced rapid and marked increases in [Ca2+]i. These effects were inhibited by D600 a calcium channel blocker. [Ca2+]i changes induced by VRT were also blocked by tetrodotoxin (TTX). Glomus cells exhibited a slow increase in [Ca2+]i in response to anoxia and CN-, and a slight decrease during hyperoxia. The effects of anoxia and CN- were blocked by D600 but not by TTX. We conclude that these stimuli induce calcium entry into glomus cells via voltage-dependent Ca2+ channels. Voltage-dependent Na+ channels were not involved.
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