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  • Title: Hemophagocytic lymphohistiocytosis onset during induction therapy for precursor B-cell acute lymphoblastic leukemia.
    Author: Breakey VR, Abdelhaleem M, Weitzman S, Abla O.
    Journal: J Pediatr Hematol Oncol; 2008 Dec; 30(12):956-8. PubMed ID: 19131791.
    Abstract:
    We report the clinical course of a child with precursor B-cell acute lymphoblastic leukemia who developed fever, hepatosplenomegaly, and refractory thrombocytopenia after initiation of chemotherapy. Bone marrow aspiration on Day 8 of induction showed new onset of hemophagocytosis and he met clinical, laboratory, and histopathologic criteria for hemophagocytic lymphohistiocytosis. His symptoms improved significantly after an increased dosage of steroids.
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