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  • Title: Cooperative DNA probing using a beta-cyclodextrin-DNA conjugate and a nucleobase-specific fluorescent ligand.
    Author: Ihara T, Uemura A, Futamura A, Shimizu M, Baba N, Nishizawa S, Teramae N, Jyo A.
    Journal: J Am Chem Soc; 2009 Feb 04; 131(4):1386-7. PubMed ID: 19132898.
    Abstract:
    A single nucleotide polymorphism (SNP) base on the target is displayed at a gap in a ternary duplex carrying beta-cyclodextrin-modified DNA. A stable tandem duplex forms regardless of the type of SNP base. A nucleobase-specific ligand is then added to this system. The dansyl moiety in the ligand is expected to form a luminous inclusion complex with nearby beta-CyD, only when the ligand recognizes the specific base displayed in the gap.
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