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  • Title: Solitary fibrous tumour of the kidney with sarcomatous overgrowth. Case report and review of the literature.
    Author: Magro G, Emmanuele C, Lopes M, Vallone G, Greco P.
    Journal: APMIS; 2008 Nov; 116(11):1020-5. PubMed ID: 19133003.
    Abstract:
    Solitary fibrous tumour (SFT) rarely occurs in the kidney, with only one case exhibiting malignant behaviour. We report the case of a typical SFT of the kidney with sarcomatous overgrowth in a 34-year-old woman. This malignant component, grossly apparent as a nodular area arising in the context of the main tumour mass, consisted of CD34+ mitotically active atypical plump spindle- to epithelioid-shaped cells, including pleomorphic multinucleated giant cells. A novel immunohistochemical finding was diffuse and strong S-100 protein expression by sarcomatous cells. This should be kept in mind by pathologists to avoid confusion with other S-100 protein-positive malignant neoplasms.
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