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  • Title: Effect of porcine small intestinal submucosa on acute full-thickness wounds in dogs.
    Author: Schallberger SP, Stanley BJ, Hauptman JG, Steficek BA.
    Journal: Vet Surg; 2008 Aug; 37(6):515-24. PubMed ID: 19134100.
    Abstract:
    OBJECTIVE: To evaluate the effects of porcine small intestinal submucosa (PSIS) on the healing of full-thickness wounds in dogs, specifically the appearance of granulation tissue, percent epithelialization and contraction, histologic variables of inflammation and repair, and aerobic culture results. STUDY DESIGN: Prospective, controlled, experimental study. ANIMALS: Purpose-bred, female dogs (n=10). METHODS: Wounds were created bilaterally on the trunk; 1 side as a control and 1 treated with PSIS. First appearance of granulation tissue was recorded. Total wound area, open wound area, and epithelialized area were measured at 21 time points-wound contraction and percent epithelialization were calculated. Aerobic cultures were taken at 4 time points and wound biopsies at 8. Histologic features were graded into an Acute Inflammation Score and Repair Score. RESULTS: There was no difference in first appearance of granulation tissue between PSIS-treated and control wounds. Wound contraction was significantly faster in control wounds as was percent epithelialization after day 21. Histologic Acute Inflammation Scores were significantly higher in PSIS-treated wounds compared with control wounds on days 2 and 6. There were no differences in Histologic Repair Scores between PSIS-treated and control wounds or in aerobic culture results. CONCLUSION: Wounds treated with PSIS contract more slowly, epithelialize less, and have more pronounced acute inflammation after implantation than control wounds. CLINICAL RELEVANCE: Acute, full-thickness wounds in dogs do not benefit from treatment with PSIS.
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