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  • Title: [Radiation-induced maxillary malignancies: complications of radiotherapy treatment for head-neck malignant tumors].
    Author: Wang JN, Li RY, Cui MY.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2008 Dec; 43(12):713-5. PubMed ID: 19134344.
    Abstract:
    OBJECTIVE: To investigate the incidence of radiation-induced maxillary malignancy after radiotherapy for head and neck cancer. METHODS: A total of 273 patients who suffered from osteoradionecrosis after radiotherapy for head and neck cancer were evaluated. Among them, 6 patients were presented with carcinoma and sarcoma arising from maxillary area after radiotherapy. RESULTS: Radiation-induced maxillary cancers happened at a rate of 2.2% in the patients with osteoradionecrosis. There were no statistically significant differences in age, sex and the time interval between the radiotherapy and the cancer occurrence. CONCLUSIONS: Radiation-induced malignancy after radiotherapy for head and neck cancer is mainly located in maxilla, presenting as squamous cell carcinoma or sarcoma of the maxillary sinus.
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