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  • Title: Novel class of hybrid natural products as antidiabetic agents.
    Author: Raj K, Misra N, Pachauri G, Sharma M, Tamrakar AK, Singh AB, Srivastava AK, Phani Kiran K, Narasimha Rao CV, Prubhu SR.
    Journal: Nat Prod Res; 2009; 23(1):60-9. PubMed ID: 19140071.
    Abstract:
    A number of O-alkylated xanthone, carbazoles and coumarins have been synthesised and screened for their in vitro anti-diabetic activity, such as glucose-6-phosphatase, glycogen phosphorylase and alpha glucosidase inhibitors. Compounds which were showing significant percentage inhibition were also tested for in vivo anti-hyperglycemic activity in sucrose loaded normal and streptozotocin (STZ)-induced diabetic rats. These compounds show 22.1, 24.4 and 26.7% and 20.8, 25.0, 20.5% lowering in sucrose loaded normal rats and STZ-induced diabetic rats at a dose of 100 mg kg(-1).
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