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  • Title: [NF-kappaB modulates activation of the BMP-2 gene by trichostatin A].
    Author: Li X, Bai XZ.
    Journal: Mol Biol (Mosk); 2008; 42(6):990-6. PubMed ID: 19140318.
    Abstract:
    In this study, we investigated trichostatin A (TSA), a histone deacetylase inhibitor, increased the Bone morphogenetic protein-2 (BMP-2) mRNA level in human osteoblasts line. Deletion analysis of the promoter region revealed that TSA-induced luciferase was regulated by the BMP-2 promoter spanning from -320 to-310. Electrophoresis mobility shift assay (EMSA) and Chromatin immunoprecipitation (CHIP) assay proved that this position was nuclear factor NF-kappaB responsive element. The results above demonstrated that acetylation plays a crucial role in BMP-2 expression and acetylation of NF-kappaB p65 and p50 subunits by TSA treatment may activate the BMP-2 promoter.
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