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  • Title: [Characterization of the drug resistance spectrum of rifampicin-resistant M. tuberculosis to other first-line antituberculous drugs].
    Author: Isakova ZhT, Goncharova ZK, Aldashev AA.
    Journal: Probl Tuberk Bolezn Legk; 2008; (11):39-42. PubMed ID: 19140379.
    Abstract:
    The spectrum of drug-resistance of rifampicin-resistant M. tuberculosis strains to other first-line antituberculous drugs was studied. Streptomycin resistance was found to be prevalent in the structure of monoresistance. Resistance to two agents--isoniazid and streptomycin--was more common in the structure of polyresistance; that to a combination of isoniazid, rifampicin, and streptomycin was seen in the structure of multidrug resistance. The rifampicin-resistant strains were also resistance to isoniazid and streptomycin in 95.1 and 98.7% of cases, respectively. Resistance to isoniazid, streptomycin, and ethambutol occurs more frequently when cytosine is substituted for thymidine (TCG-->TTG) in codon 513 of the rpoB gene.
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