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  • Title: Microscopic colitis associated with omeprazole and esomeprazole exposure.
    Author: Wilcox GM, Mattia AR.
    Journal: J Clin Gastroenterol; 2009 Jul; 43(6):551-3. PubMed ID: 19142168.
    Abstract:
    GOALS: The aim of this study was to determine whether proton pump inhibitors other than lansoprazole might be associated with microscopic colitis. BACKGROUND: Lansoprazole exposure has been associated with diarrhea and microscopic colitis, but this relationship has not been described with other proton pump inhibitors. STUDY: Cases of microscopic colitis from a consultative gastroenterology practice were collected and reviewed for proton pump inhibitor exposure. Standard clinical, endoscopic, and biopsy findings were analyzed. RESULTS: A case series of 4 patients is described in which subjects developed classic symptoms of lymphocytic-collagenous colitis with typical mucosal histopathology during treatment with omeprazole/esomeprazole. Symptoms promptly stopped and mucosal biopsies returned to normal with drug withdrawal. Disease quickly recurred in 2 patients who were reexposed to the drugs, one with biopsy documented recurrent collagenous colitis. CONCLUSIONS: Some cases of microscopic colitis seem to be associated with omeprazole/esomaprazole exposure. These results have epidemiologic, diagnostic, and therapeutic ramifications, which are discussed.
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