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  • Title: Effect of interleukin-1 on hyaluronate synthesis by synovial fibroblastic cells.
    Author: Konttinen YT, Saari H, Nordström DC.
    Journal: Clin Rheumatol; 1991 Jun; 10(2):151-4. PubMed ID: 1914415.
    Abstract:
    Interleukin-1 (IL-1) stimulates fibroblast-mediated hyaluronate (HA) synthesis in vitro. In the present study the degree of polymerization of such HA was studied using HPLC (high performance liquid chromatography) with a size exclusion column combined with 125I-HABP assay used to measure the HA concentration in various HA molecular weight fractions separated using HPLC. IL-1 stimulated HA was more polydisperse than that produced by resting fibroblasts with a molecular weight varying from more than 4 x 10(6) daltons to less than 7.1 x 10(3) daltons. This IL-1 effect may contribute to the low molecular weight HA produced by freshly explanted arthritic synovial tissue and to the low viscosity of arthritic synovial fluid in vivo.
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