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  • Title: In vivo testing of nanoparticle-treated TTCP/DCPA-based ceramic surfaces.
    Author: Chen WC, Ju CP, Tien YC, Lin JH.
    Journal: Acta Biomater; 2009 Jun; 5(5):1767-74. PubMed ID: 19144582.
    Abstract:
    This study reports the development of a non-dispersive calcium phosphate cement (nd-CPC) paste containing tetracalcium phosphate and anhydrous dicalcium phosphate that can be used as a filling material in dental and orthopedic applications. The nd-CPC bone cement is compared with two commercial materials, OsteoSet and Collagraft bone grafts. Gross examination of retrieved implants/bone composite samples indicated that none of the implants in this study evoked an inflammatory response. The OsteoSet (calcium sulfate) implant was resorbed too quickly to allow for osteo-remodeling, and it led to the formation of fibrous connective tissue in the fracture site, which remained even 24 weeks after implantation. Histological examination revealed that nd-CPC and Collagraft (hydroxyapatite/tricalcium phosphate/collagen) had greater remodeling and osteoconductive activity than OsteoSet at both 12 and 24 weeks after implantation. Greater remodeling activities were found with nd-CPC cement than with the other materials at 12 weeks after implantation, and the Fourier transform infrared absorption band of carbonate or cellulose derivatives grew from 6 weeks to 24 weeks after implantation in nd-CPC cement. These findings show that nd-CPC compares favorably to commercial bone remodeling materials, and the fact that it is in a paste formulation makes it an ideal material to fill regeneration defects.
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