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  • Title: Metabolism in rats during antiorthostatic hypokinesia.
    Author: Novoselova AM, Custaud MA, Tsvirkun DV, Larina IM, Kulchitsky VA.
    Journal: Bull Exp Biol Med; 2008 Jul; 146(1):38-40. PubMed ID: 19145345.
    Abstract:
    O2 consumption and CO2 release in 3 groups of awake rats were studied on a MM-100 metabolic monitor system (CWE Inc.). The animals of 2 groups were preadapted to 4-h maintenance in special boxes (2 weeks). The rats could perform rotational movements and limited movements in the rostrocaudal direction (hypokinesia). The animals of one group were daily exposed to 4-h antiorthostatic load (<or=45 degrees) for 2 weeks. After 2 weeks, the intensity of metabolism in rats with antiorthostatic hypokinesia was lower than in hypokinetic specimens (by 15-20%, p<0.05) and freely moving animals (by 20-25%, p<0.05). Interleukin-6 concentration in rats with antiorthostatic hypokinesia (0.25+/-0.09 pg/ml) was lower than in hypokinetic (4.01+/-0.57 pg/ml) and freely moving animals (3.69+/-0.56 pg/ml). The decrease in the concentration of a proinflammatory cytokine interleukin-6 during experimental antiorthostatic hypokinesia reflects inhibition of metabolic processes, which are activated during antiorthostatism (but not hypokinesia).
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