These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors.
    Author: Abell AD, Jones MA, Coxon JM, Morton JD, Aitken SG, McNabb SB, Lee HY, Mehrtens JM, Alexander NA, Stuart BG, Neffe AT, Bickerstaffe R.
    Journal: Angew Chem Int Ed Engl; 2009; 48(8):1455-8. PubMed ID: 19145612.
    Abstract:
    The design and elaboration of a series of macrocyclic templates that exhibit a propensity to adopt a beta-strand-like peptide-backbone conformation led to potent and selective inhibitors of calpain 2. Macrocycle 1 retarded calcium-induced opacification in an ovine-lens culture assay and is a lead compound for the development of a drug for cataract treatment. Cbz=carbobenzyloxy.
    [Abstract] [Full Text] [Related] [New Search]