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  • Title: Nephro-protective effect of Kangqianling decoction on chronic renal failure rats.
    Author: He L, Shen P, Fu Q, Li J, Dan M, Wang X, Jia W.
    Journal: J Ethnopharmacol; 2009 Mar 18; 122(2):367-73. PubMed ID: 19146937.
    Abstract:
    ETHNOPHARMACOLOGICAL RELEVANCE: Kangqianling decoction (KQL), the modified formulation of a classical Chinese prescription named Taohongsiwu decoction, was clinically employed to treat renal fibrosis in chronic renal failure. AIM OF THE STUDY: The present study was designed to examine whether KQL has a protective effect on renal function in association with transforming growth factor-beta (TGF-beta), angiotensin II (Ang II), tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappaB (NF-kappaB) in rats with 5/6 renal ablation (Nx)-induced chronic renal failure. RESULTS: In renal function deterioration progression, the high expression of serum creatinine (Scr), 24-h urine protein and systolic blood pressure were markedly (P<0.05 or P<0.01) restored by KQL, respectively, at 4 and 8 weeks. The increasing expressions of renal Ang II (P<0.05), angiotensin II1-receptor (AT1R) (P<0.05), TNF-alpha (P<0.05), NF-kappaB (P<0.001) and urine TGF-beta1 (P<0.05) were reduced by the treatment of KQL. Immunohistochemical study further confirmed the nephro-protective activity of KQL as compared to the control and Sham group. CONCLUSIONS: The results indicate that KQL is able to protect renal function via ameliorating experimental rat renal failure as found in these renal functional parameters.
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