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  • Title: Prediction of developing metabolic syndrome after gestational diabetes mellitus.
    Author: Akinci B, Celtik A, Yener S, Yesil S.
    Journal: Fertil Steril; 2010 Mar 01; 93(4):1248-54. PubMed ID: 19147138.
    Abstract:
    OBJECTIVE: To determine the predictors of subsequent development of metabolic syndrome (MS) in women with previous gestational diabetes mellitus (GDM). DESIGN: Controlled clinical study. SETTING: University hospital. PATIENT(S): One hundred sixty-four consecutive women with previous GDM were evaluated after a mean follow-up of 40.54 months from index pregnancy. Sixty-five lean women with negative screening for GDM were included as a control group. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Subjects were evaluated for diagnosis of MS according to criteria of the National Cholesterol Education Program and the International Diabetes Federation. Tests were performed including a 75-g oral glucose tolerance test (OGTT), fasting insulin, lipids, plasma fibrinogen, blood pressure, and body measurements. The homeostasis model assessment score was calculated. RESULT(S): The MS prevalence was higher in women with previous GDM, according to both definitions. Univariate analysis showed that prepregnancy obesity, weight gain during follow-up, and fasting glucose level at the OGTT of the index pregnancy were predictors of developing MS. Multivariate analysis showed that fasting glucose level >100 mg/dL at the OGTT of the index pregnancy was an independent predictor of the MS development. CONCLUSION(S): We suggest that early prediction of women with previous GDM who are at high risk for developing MS is possible, and it is vital to prevent MS-related complications.
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