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  • Title: Acquired epidermodysplasia verruciformis.
    Author: Rogers HD, Macgregor JL, Nord KM, Tyring S, Rady P, Engler DE, Grossman ME.
    Journal: J Am Acad Dermatol; 2009 Feb; 60(2):315-20. PubMed ID: 19150275.
    Abstract:
    Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis with an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, this viral infection leads to the development of tinea versicolor-like macules on the trunk, neck, arms, and face during childhood, and over time, these lesions can progress to squamous cell carcinoma. More recently, an EV-like syndrome has been described in patients with impaired cell-mediated immunity. We describe two cases of EV-like syndrome in HIV-positive patients, review all previously reported cases of EV in patients with impaired cell-mediated immunity, introduce the term "acquired epidermodysplasia verruciformis" to describe EV developing in the immunocompromised host and examine the limited treatment options for these patients.
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