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  • Title: Stability of chemical and immunochemical analytes in uncentrifuged plasma samples.
    Author: Leino A, Koivula MK.
    Journal: Ann Clin Biochem; 2009 Mar; 46(Pt 2):159-61. PubMed ID: 19151172.
    Abstract:
    BACKGROUND: The stability of analyte concentrations in plasma after prolonged contact with blood cells in uncentrifuged lithium-heparin gel tubes was studied. METHODS: To investigate the stability of concentrations of 26 chemistry and 15 immunochemistry analytes, the simultaneously drawn samples (n = 50) were measured after 6 h storage at +8 degrees C and +22 degrees C in whole blood and after immediate separation of plasma. The analyte concentrations were measured with a Roche Modular PPEE analyser using reagents from Roche Diagnostics. RESULTS: After prolonged contact with cells a clinically significant change was only observed for potassium where the mean value increased from 4.0 mmol/L to 4.8 mmol/L (P < 0.001) when stored at +8 degrees C. CONCLUSION: Immediate separation of plasma from cells is recommended. However, when prolonged contact of plasma with cell is unavoidable, samples can be kept uncentrifuged for up to 6 h at +8 degrees C or at +22 degrees C. The stability of potassium, however, is temperature-dependent and cannot be measured from refrigerated blood samples.
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