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  • Title: Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors.
    Author: Nelson JK, Frølund SU, Tikhonov DB, Kristensen AS, Strømgaard K.
    Journal: Angew Chem Int Ed Engl; 2009; 48(17):3087-91. PubMed ID: 19152392.
    Abstract:
    More discerning than the parent: Analogues of the polyamine toxin argiotoxin 636 (shown docked in the ion channel of an ionotropic glutamate (iGlu) receptor; N blue, O red) distinguish subtypes of iGlu receptors. Depending on which of the two internal amine groups is replaced with a methylene group, the analogue inhibits one or other of two receptor subtypes as potently as the natural compound, which itself inhibits both subtypes nonselectively.
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