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  • Title: Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.
    Author: Doiron J, Boudreau LH, Picot N, Villebonet B, Surette ME, Touaibia M.
    Journal: Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1118-21. PubMed ID: 19152786.
    Abstract:
    Novel cinnamoyl and caffeoyl clusters were synthesized by multiple Cu(I)-catalyzed [1,3]-dipolar cycloadditions and their anti-5-lipoxygenase inhibitory activity was tested. Caffeoyl cluster showed an improved 5-lipoxygenase inhibitory activity compared to caffeic acid, with caffeoyl trimer 16 and tetramer 19 showing the best 5-lipoxygenase inhibitory activity.
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