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  • Title: Influence of H-2 complex on susceptibility to infection by murine leukemia virus.
    Author: Tucker HSt, Weens J, Tsichlis P, Schwartz RS, Khiroya R, Donnelly J.
    Journal: J Immunol; 1977 Apr; 118(4):1239-43. PubMed ID: 191531.
    Abstract:
    Titers of infectious ecotropic MuLV in mouse spleen were examined after deliberate infection. In congenic mice differing only in H-2 haplotype, a gene (or genes) within the H-2 complex determined either a high virus titer (H-2k, H-2d, H-2a) or a low titer (H-2b, H-2q). Susceptibility to high virus titers was inherited as a dominant trait. Kinetic studies revealed similar initial patterns of infection in both groups, with a fall in titer in the "resistant" strain occurring from week 6 through 10 after infection. Anti-VEA antibody titers differed significantly between the groups, but no mechanistic role for antibody in eliminating virus was apparent. Genes outside the H-2 complex were shown to influence MuLV titers after infection as well.
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