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  • Title: Candidaemia: incidence, risk factors, characteristics and outcomes in immunocompetent critically ill patients.
    Author: Vardakas KZ, Michalopoulos A, Kiriakidou KG, Siampli EP, Samonis G, Falagas ME.
    Journal: Clin Microbiol Infect; 2009 Mar; 15(3):289-92. PubMed ID: 19154488.
    Abstract:
    A matched case-control study was conducted to determine the risk factors for development of candidaemia in patients requiring intensive-care unit (ICU) treatment for more than 48 h. Patients were matched according to length of ICU stay, age, department of admission, year of admission and sex. Forty-five patients with candidaemia were identified (0.6 cases/1000 patient-days). Candidaemia developed mainly in critically ill patients with multiple organ failure and end-stage disease. Candida colonization and gastrointestinal surgery were independently associated with candidaemia. ICU and total in-hospital mortality were 40% and 66.7%, respectively. Candidaemia-related mortality was 20%. Candidaemia treatment failure was the only variable associated with in-hospital mortality (p 0.008).
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