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  • Title: Memory with emotional content, brain amygdala and Alzheimer's disease.
    Author: Schultz RR, de Castro CC, Bertolucci PH.
    Journal: Acta Neurol Scand; 2009 Aug; 120(2):101-10. PubMed ID: 19154540.
    Abstract:
    OBJECTIVES: A highly adaptive aspect of human memory is the enhancement of explicit, consciously accessible memory by emotional stimuli. We studied the performance of Alzheimer's disease (AD) patients and elderly controls using a memory battery with emotional content, and we correlated these results with the amygdala and hippocampus volume. METHODS: Twenty controls and 20 early AD patients were subjected to the International Affective Picture System (IAPS) and to magnetic resonance imaging-based volumetric measurements of the medial temporal lobe structures. RESULTS: The results show that excluding control group subjects with 5 or more years of schooling, both groups showed improvement with pleasant or unpleasant figures for the IAPS in an immediate free recall test. Likewise, in a delayed free recall test, both the controls and the AD group showed improvement for pleasant pictures, when education factor was not controlled. The AD group showed improvement in the immediate and delayed free recall test proportional to the medial temporal lobe structures, with no significant clinical correlation between affective valence and amygdala volume. CONCLUSION: AD patients can correctly identify emotions, at least at this early stage, but this does not improve their memory performance.
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