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Title: A palladium(II)-catalyzed synthesis of spiroacetals through a one-pot multicomponent cascade reaction. Author: Barluenga J, Mendoza A, Rodríguez F, Fañanás FJ. Journal: Angew Chem Int Ed Engl; 2009; 48(9):1644-7. PubMed ID: 19156654. Abstract: Functionalized spiroacetals have been easily prepared in a one-pot three-component coupling process that involves the reaction of pentynol derivatives, salicylaldehydes, and amines in the presence of catalytic amounts of a palladium(II) complex (see scheme). Alternatively, oxygen-substituted spiroacetals can be obtained by using orthoesters as the third component.[Abstract] [Full Text] [Related] [New Search]