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  • Title: [Determination of plasma homocysteine in oligospermia and/or asthenospermia patients].
    Author: Ge YF, Wang CH, Ouyang LX, Shao Y, Yao B, Xia XY, Shang XJ, Huang YF.
    Journal: Zhonghua Nan Ke Xue; 2008 Dec; 14(12):1112-4. PubMed ID: 19157234.
    Abstract:
    OBJECTIVE: To detect the level of fasting plasma homocysteine (Hcy) in patients with oligospermia and/or asthenospermia and to investigate its clinical significance. METHODS: Semen quality analyses and fasting plasma Hcy determination were performed for 86 infertility patients (21 with oligospermia, 32 with asthenospermia and 33 with oligo-asthenospermia) and 19 normal fertile volunteers. The results were compared. RESULTS: The level of plasma Hcy was significantly higher in the infertility patients than in the normal controls (P < 0.05) and negatively correlated with sperm concentration (r = -0.433, P < 0.01), the percentage of grade a sperm (r = -0.303, P < 0.05) and the percentage of grade a+b sperm (r = -0.339, P < 0.01). CONCLUSION: The increased level of human plasma Hcy directly or indirectly affects spermatogenesis and correlates negatively with oligospermia and/or asthenospermia.
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