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  • Title: On the mechanism of oligomycin inhibition of Ca(2+)-induced mitochondrial respiration.
    Author: Krasinskaya IP, Kudryashova IA, Yaguzhinsky LS.
    Journal: FEBS Lett; 1991 Sep 23; 290(1-2):52-4. PubMed ID: 1915891.
    Abstract:
    The addition of oligomycin in the presence of Ca2+ increased the ADP pool in mitochondrial suspension. It is suggested that oligomycin inhibition of Ca(2+)-induced mitochondrial respiratory activation is the function of the increased endogenous ADP pool. Low ADP concentrations (5-20 microM) produce the same inhibitory effect as oligomycin. The increase of ADP levels in the presence of glucose plus hexokinase resulted in the inhibition of Ca(2+)-induced respiration, while the addition of phosphoenol pyruvate plus pyruvate kinase followed by a reduction in ADP levels, reversed the oligomycin inhibitory effect. One of the essential stages of ADP accumulation in mitochondrial suspensions in the presence of oligomycin and Ca2+ is proposed to be the formation of ADP from AMP and ATP, effected by adenylate kinase.
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