These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of Shen-song-yang-xin capsule on ventricular arrhythmias in ischemia/reperfusion: experiment with rats].
    Author: Ren JY, Li LJ, Wang RJ, Chen H, Wu YL, Luo Y.
    Journal: Zhonghua Yi Xue Za Zhi; 2008 Dec 30; 88(48):3440-3. PubMed ID: 19159580.
    Abstract:
    OBJECTIVE: To investigate the effects of Shen-song-yang-xin capsule containing ginseng, ophiopogon root, red sage root, etc, on the ventricular arrhythmias caused by ischemic/reperfusion. METHODS: Thirty SD rats were randomly divided into 2 equal groups: Shen-song-yang-xin group undergoing gastric infusion of Shen-song-yang-xin 4 g x kg(-1) x d(-1) for 2 weeks and then subjected to left coronary artery occlusion for 30 minutes followed by reperfusion for 60 minutes, and control group undergoing ischemia/reperfusion only. Electrocardiography was conducted to record the ventricular arrhythmias, and after 60 minutes of reperfusion the rats were killed with their hearts removed to measure the infarction size. RESULTS: (1) During the 30 minutes' ischemia, the average number of episode of ischemia-induced premature ventricular contraction of the Shen-song-yang-xin group was (6.7 +/- 0.3) beats/30 min, significantly lower than that of the control group [(15.0 +/- 1.1) beats/30 min, P = 0.007]; the average number of episode of ischemia-induced ventricular tachycardia of the Shen-song-yang-xin group was (3.5 +/- 0.2) episodes/30 min, significantly lower than that of the control group [(14.7 +/- 0.6) episodes/30 min, P = 0.003]; the duration of ventricular tachycardia of the Shen-song-yang-xin group was (10.3 +/- 2.0) s, significantly shorter than that of the control group [(28.3 +/- 4.6) s, P = 0.018]; and the duration of ventricular fibrillation of the Shen-song-yang-xin group was (7.0 +/- 1.1) s, significantly shorter than that of the control group [(15.0 +/- 1.7) s, P = 0.031]. (2) 60 minutes after the reperfusion, the number of episode of premature ventricular contraction of the Shen-song-yang-xin group was (5.3 +/- 0.8) beats/60 min, significantly lower than that of the control group [(15.6 +/- 1.8) beats/60 min, P = 0.002], and the duration of reperfusion-induced ventricular tachycardia was (4.6 +/- 0.5) s, significantly shorter than that of the control group [(13.5 +/- 0.6) s, P = 0.001]. CONCLUSION: Shen-song-yang-xin capsule significantly reduces the ischemia-induced ventricular arrhythmia, average episode number of reperfusion-induced premature ventricular contraction, and duration of reperfusion-induced ventricular tachycardia.
    [Abstract] [Full Text] [Related] [New Search]