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  • Title: [Load of hereditary diseases in the populations of the Adyg autonomic district].
    Author: Petrin AN, Ginter EK, Golubtsov VI, Kadoshnikova MIu, Galkina VA, Khlebnikova OV, Mikhaĭlova LK, Poleshchuk VV, Sukolin GI.
    Journal: Genetika; 1991 May; 27(5):911-9. PubMed ID: 1916257.
    Abstract:
    Comparative analysis of the loads of hereditary diseases in two ethnically different populations coexisting in the Adyg national district was performed. The modes of inheritance of diseases studied were tested by segregational analysis. The results obtained demonstrated that the load of autosomal-recessive diseases in the populations of the Adyg national district is higher than that in Russian population, while the load of autosomal-dominant diseases is similar in two populations. This difference in the level of the loads appear to be connected with genetic structure of the populations studied. Regressional analysis of relations between loads and the level of inbreeding in the Adyg population showed the explicit interrelation between the load of autosomal-dominant diseases and the Fst correlation coefficient being 0.89.
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