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  • Title: Fluorescence signal amplification by cation exchange in ionic nanocrystals.
    Author: Li J, Zhang T, Ge J, Yin Y, Zhong W.
    Journal: Angew Chem Int Ed Engl; 2009; 48(9):1588-91. PubMed ID: 19165850.
    Abstract:
    Lighting-up time: A cation-exchange reaction releases thousands of divalent cations from nonfluorescent CdSe ionic crystals and triggers fluorescence from thousands of originally nonfluorescent Fluo-4 fluorophores to obtain a large fluorescence amplification (see picture) and a low detection limit in bioassays. The technique is fast, simple, with a large dye-to-reporter labeling ratio, and flexible in selection of nanocrystals and fluorophores.
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