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  • Title: Use of multiple-reaction monitoring ratios for identifying incompletely resolved fentanyl homologs and analogs via ultra-high-pressure liquid chromatography-tandem mass spectrometry.
    Author: Lurie IS, Iio R.
    Journal: J Chromatogr A; 2009 Feb 27; 1216(9):1515-9. PubMed ID: 19167002.
    Abstract:
    Fentanyl and 16 of its corresponding homologs and analogs were distinguished using ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). A 1.7 microm Acquity BEH C18 column (150 mm x 2.1 mm) was used with a 1% formic acid (pH 2.2), methanol gradient. Multiple-reaction monitoring (MRM) was employed for MS/MS detection. All selected fentanyl-related compounds, including incompletely resolved compounds, were uniquely identified using retention times and dual MRMs.
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