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  • Title: Synthesis and promotion angiogenesis effect of chrysin derivatives coupled to NO donors.
    Author: Peng SM, Zou XQ, Ding HL, Ding YL, Lin YB.
    Journal: Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1264-6. PubMed ID: 19167219.
    Abstract:
    Two types of new chrysin derivatives were prepared by coupling NO donors of alkyl nitrate and furazan derivatives and were fully characterized by (1)H NMR and other techniques. These compounds were tested in human umbilical vein endothelial cells (HUVECs-12) and all the compounds exhibited cell proliferation. Notable effects of promoting angiogenesis were observed for all the modified compounds using chick chorioallantoic membrane (CAM) assay.
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