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  • Title: Mechanical property analysis of stored red blood cell using optical tweezers.
    Author: Li Y, Wen C, Xie H, Ye A, Yin Y.
    Journal: Colloids Surf B Biointerfaces; 2009 May 01; 70(2):169-73. PubMed ID: 19168336.
    Abstract:
    The deformation of human red blood cells subjected to direct stretching by optical tweezers was analyzed. The maximum force exerted by optical tweezers on the cell via a polystyrene microbead 5microm in diameter was 315pN. Digital image correlation (DIC) method was introduced to calculate the force and the deformation of the cell for the first time. Force-extension relation curves of the biconcave cell were quantitatively assessed when erythrocytes were stored in Alsever's Solution for 2 days, 5 days, 7 days and 14 days respectively. Experiment results demonstrated that the deformability of red blood cells was impaired with the stored time.
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