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  • Title: Idiotype specific T-cell lines inducing experimental systemic lupus erythematosus in mice.
    Author: Fricke H, Mendlovic S, Blank M, Shoenfeld Y, Ben-Bassat M, Mozes E.
    Journal: Immunology; 1991 Aug; 73(4):421-7. PubMed ID: 1916893.
    Abstract:
    Immunization of mice with either antibodies bearing the 16/6 idiotype (16/6 Id) or anti-idiotypic antibodies against the 16/6 Id induces experimental systemic lupus erythematosus (SLE). We report here the establishment and characterization of 16/6 Id-specific T-cell lines from C3H.SW (H-2b) and BALB/c (H-2d) mice. Both lines proliferate specifically in response to the 16/6 Id in an H-2-restricted manner. The injection of 16/6 Id-specific T cells into syngeneic mice led to the development of experimental SLE. Furthermore, inoculation of the 16/6 Id-specific T-cell line derived from C3H.SW mice into the H-2 compatible C57BL/6 mice, which are non-responders to the 16/6 Id, induced experimental SLE. This report provides direct evidence for the role of idiotype-specific T cells in the induction of experimental SLE.
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