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  • Title: Peripheral nerve vasculitis presenting as complex regional pain syndrome.
    Author: Ramchandren S, Chaudhry V, Hoke A, Murinson BB, Cornblath DR, Treisman GJ, Griffin JW.
    Journal: J Clin Neuromuscul Dis; 2008 Dec; 10(2):61-4. PubMed ID: 19169092.
    Abstract:
    OBJECTIVE: To report the clinical, electrodiagnostic, and pathologic findings in 3 patients who presented with complex regional pain syndrome as their primary manifestation of peripheral nerve vasculitis. DESIGN: Case series. SETTING: Outpatient clinic in a tertiary care academic medical center. PATIENTS: Patient 1 was a 39-year-old woman with a 9-year history of non-length-dependent severe burning pain and swelling in her extremities. Patient 2 was a 67-year-old man with a 2-year history of severe burning pain and swelling in an extremity after a fall. Patient 3 was a 74-year-old man with a 6-month history of severe allodynic pain and atrophy of the right hand after a viral illness RESULTS: In all 3 cases, clinical and electrodiagnostic testing were suggestive of multiple mononeuropathies. Nerve biopsy either confirmed vasculitis (patient 1) or was suggestive of angiopathy (patients 2 and 3). Immunomodulative therapy led to marked clinical improvement in all 3 cases. CONCLUSIONS: To our knowledge, this is the first report demonstrating that the inflammatory nerve injury seen with peripheral nerve vasculitis can result in complex regional pain syndrome. Clinical and electrodiagnostic assessments can help in the identification and management of these patients.
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