These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: Determination of anti-malaria agent chloroquine using single drop liquid-liquid-liquid microextraction.
    Author: Daneshfar A, Khezeli T, Manafi MH.
    Journal: J Sep Sci; 2009 Feb; 32(4):511-6. PubMed ID: 19173322.
    Abstract:
    A simple, sensitive, and inexpensive single drop liquid-liquid-liquid microextraction combined with isocratic RP-HPLC and UV detection was developed for the determination of anti-malaria drug, chloroquine. The target compound was extracted from alkaline aqueous sample solution (adjusted to 0.5 mol/L sodium hydroxide) through a thin layer of organic solvent membrane and back-extracted to an acidic acceptor drop (adjusted to 0.02 mol/L phosphoric acid) suspended on the tip of a 25 microL HPLC syringe in the organic layer. This syringe was also used for direct injection after extraction. The linear range was 1-200 microg/L. The LOD and LOQ were 0.3 and 1.0 microg/L, respectively. Intra-and inter-day precisions were less than 2.0 and 2.3%, respectively. The real samples were successfully analyzed using the proposed method. The recoveries of spiked samples were more than 94.6%.
    [Abstract] [Full Text] [Related] [New Search]