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  • Title: Selectivity in ligand recognition of G-quadruplex loops.
    Author: Campbell NH, Patel M, Tofa AB, Ghosh R, Parkinson GN, Neidle S.
    Journal: Biochemistry; 2009 Mar 03; 48(8):1675-80. PubMed ID: 19173611.
    Abstract:
    A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.
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