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  • Title: An experimental osteosarcoma of the athymic nude rat.
    Author: Witzel JG, Prescher A.
    Journal: Invasion Metastasis; 1991; 11(2):110-5. PubMed ID: 1917384.
    Abstract:
    In this report we describe an experimental osteogenic sarcoma that had been radiation-induced on Sprague-Dawleys by Delbrück in 1980. We transplanted it to 120 athymic nude rats achieving take rates of 100%. The tumor doubling time was 10.5 days. The osteosarcoma on athymic rats thus proliferated extraordinarily well compared to other known models. Pulmonary metastases were demonstrated in 100% of the examined animals. Pathological examinations revealed morphological similarities to human osteosarcoma and no signs of anaplasia.
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