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  • Title: [A Meta-analysis on the association between adiponectin gene 45T/G/276G/T polymorphisms and type 2 diabetes in Chinese population].
    Author: Xu MT, Chen XC, Jin LZ, Chen WQ.
    Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 2008 Nov; 29(11):1132-6. PubMed ID: 19173941.
    Abstract:
    OBJECTIVE: Association between the 45T/G and 276G/T single nucleotide polymorphisms of adiponectin gene and the occurrence of type 2 diabetes in Chinese population was studied. METHODS: 20 studies consisting 22 case-control comparisons about 45T/G polymorphism and nine case-control studies about 276G/T polymorphism that were based on our inclusion criterion and available in the literature were reviewed. RESULTS: Results from Meta-analysis demonstrated a large heterogeneity among the studies both on 45T/G and 276G/T polymorphisms and a significant association was observed between 45T/G polymorphism at exon 2 of the adiponectin gene and type 2 diabetes among the Chinese population.45G allele appeared to be one of the genetic risk factors for susceptibility to type 2 diabetes with a random effects odds ratio (OR) of 1.43 (95%CI: 1.17 - 1.75), and the G allele carriers were more susceptible to the disease with an OR of 1.38 (95%CI: 1.04 - 1.84). Results from Meta-analysis, however, showed no association between the 276G/T polymorphism and type 2 diabetes in the Chinese population, while the random effects OR of the allele 276T to susceptibility of disease was 0.83 (95%CI: 0.61 - 1.13). CONCLUSION: The current paper on Meta-analysis demonstrated a correlation between the 45T/G single nucleotide polymorphism and the occurrence of type 2 diabetes in Chinese population, which was different from the findings that such an association with 276G/T polymorphism could not be demonstrated in the same ethnic population.
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