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  • Title: [Inductive effect of RNAi RelB dendritic cells on the CD4(+)CD25(+) T cells proliferation].
    Author: Zheng L, Yan XH, Wang Q, Bao J, Qiu YR.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2009 Feb; 25(2):104-6. PubMed ID: 19174004.
    Abstract:
    AIM: To discover the inductive proliferation effect of the RNAi RelB dendritic cells (DCs) on the heterogenic CD4(+)CD25(+) T cells in mice. METHODS: The proportion of CD4(+)CD25(+) T cells were quantification through flow cytometer when each group of DCs interact with heterogenic T cells in mixed lymphocyte reaction, including control DCs, LPS stimulated DCs, RNAi RelB DCs and LPS stimulated RNAi RelB DCs. RESULTS: Control DCs stimulate more CD4(+)CD25(+) T cells to proliferate than LPS stimulated DCs(P<0.01). RNAi RelB DCs and LPS stimulated RNAi RelB DCs significantly improved CD4(+)CD25(+) T cells proliferation compared with LPS stimulated DCs(P<0.01). RNAi RelB DCs can also induced CD4(+)CD25(+) T cells to proliferate more than Control DCs (P<0.05). CONCLUSION: RNAi RelB DCs possess powerful potential to induce CD4(+)CD25(+) T cells proliferation, one of characteristics of immature dendritic cells. This type of RNAi RelB DCs can be used as tolerogenic DCs to regulate autoimmunity and other immune responses.
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