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  • Title: Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility.
    Author: Incerti S, Seznec H, Simon M, Barberet P, Habchi C, Moretto P.
    Journal: Radiat Prot Dosimetry; 2009 Jan; 133(1):2-11. PubMed ID: 19174380.
    Abstract:
    Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes dosimetry calculations performed at the single-cell level in the microbeam irradiation facility available at the Centre d'Etudes Nucléaires de Bordeaux-Gradignan in France, using the object-oriented Geant4 Monte Carlo simulation toolkit. The cell geometry model is based on high-resolution three-dimensional voxelised phantoms of a human keratinocyte (HaCaT) cell line. Such phantoms are built from confocal microscopy imaging and from ion beam chemical elemental analysis. Results are presented for single-cell irradiation with 3 MeV incident alpha particles.
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