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  • Title: Iridium-catalyzed asymmetric hydrogenation of unfunctionalized enamines.
    Author: Baeza A, Pfaltz A.
    Journal: Chemistry; 2009; 15(10):2266-9. PubMed ID: 19177480.
    Abstract:
    Optically active tertiary amines are readily prepared by iridium-catalyzed asymmetric hydrogenation of unfunctionalized enamines (see scheme). The best enantioselectivities with >90% ee were obtained with N-aryl- and N-benzyl-substituted enamines with a terminal double bond. The hydrogenation of enamines derived from cyclic ketones, which has not been reported yet with other catalysts, gave enantiomeric excesses of up to 87%.
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