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  • Title: A new specific BACE-1 inhibitor from the stembark extract of Vitis vinifera.
    Author: Choi YH, Yoo MY, Choi CW, Cha MR, Yon GH, Kwon DY, Kim YS, Park WK, Ryu SY.
    Journal: Planta Med; 2009 Apr; 75(5):537-40. PubMed ID: 19184970.
    Abstract:
    A new resveratrol dimer, (+)-vitisinol E (1) which demonstrated inhibitory activity on BACE-1 (beta-site APP-cleaving enzyme 1) in vitro, was isolated from the stembark extract of Vitis vinifera (Vitaceae) together with four known resveratrol oligomers, (+)-epsilon-viniferin (2), (+)-ampelopsin A (3), (+)-vitisin A (4) and (-)-vitisin B (5). The chemical structure of 1 was established by MR spectroscopic analyses, including HMBC. All isolated resveratrol derivatives (1-5) demonstrated significant inhibition on baculovirus-expressed BACE-1 in a dose-dependent manner, which was assessed with the FRET assay using Rh-EVNLDAEFK as a substrate in vitro.
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