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  • Title: True osseous metaplasia of the endometrium: the bone is not from a fetus.
    Author: Cayuela E, Perez-Medina T, Vilanova J, Alejo M, Cañadas P.
    Journal: Fertil Steril; 2009 Apr; 91(4):1293.e1-4. PubMed ID: 19185859.
    Abstract:
    OBJECTIVE: To identify the origin of calcified tissue in endometrial ossification. DESIGN: DNA analyses from the ossified tissue and from the woman were studied to compare both genotypes. SETTING: University and general hospitals. PATIENT(S): A 27-year-old infertile woman diagnosed of osseous metaplasia of the endometrium. INTERVENTION(S): Hysteroscopic resection of the endometrial osseous metaplasia for DNA analysis. MAIN OUTCOME MEASURE(S): DNA comparison between the patient and the osseous tissue extracted from the uterus. RESULT(S): All markers produced the same allele length for both blood and endometrial biopsy (including bones), thus confirming the same genetic origin. CONCLUSION(S): Endometrial ossification is derived from the patient, resulting in a true osseous metaplasia.
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