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  • Title: [Effect of chlorimipramine on the so-called ponto-geniculo-occipitalactivity (PGO) in a primate, Papio hamadryas (author's transl)].
    Author: Bert J, Saier J, Tognetti P, Toure MF.
    Journal: Psychopharmacology (Berl); 1977 Mar 16; 51(3):301-4. PubMed ID: 191866.
    Abstract:
    Three hamadryas adult baboons (female) received 24 daily injections of Chlorimipramine (1.7 mg/kg). The effects on sleep were nearly identical with the effects observed in man. PGO activity, recorded in the lateral geniculate nucleus, was much disturbed. The total number of PGO fell downward from the first recording. The number of PGO/min during paradoxial sleep was even more decreased. This fact suggests a selective influence of CL I on the mechanisms of PGO activity. Is the particular effect of importance to the treatment of depression symptoms?
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