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  • Title: Modulation of human platelet adenylate cyclase by prostacyclin (PGX).
    Author: Gorman RR, Bunting S, Miller OV.
    Journal: Prostaglandins; 1977 Mar; 13(3):377-88. PubMed ID: 191876.
    Abstract:
    Prostacyclin (PGX) (57)-9-deoxy-6,9alpha-epoxy-delta5-PGF1alpha has been found to be a potent stimulator of cAMP accumulation in platelets than PGE1. The prostacyclin stimulation of platelet cAMP accumulation can be antagonized by the prostaglandin endoperoxide PGH2, and a PGH2-induced platelet aggregation is antagonized by prostacyclin. A model of platelet homeostasis is proposed that suggests platelet aggregation is controlled by a balance between the adenylate cyclase stimulating activity of prostacyclin, and the cAMP lowering activity of PGH2.
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