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  • Title: MDMA reinstates cocaine-seeking behaviour in mice.
    Author: Trigo JM, Orejarena MJ, Maldonado R, Robledo P.
    Journal: Eur Neuropsychopharmacol; 2009 Jun; 19(6):391-7. PubMed ID: 19188047.
    Abstract:
    BACKGROUND: MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse. METHODS: CD1 mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug self-administration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement. RESULTS: Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine self-administration and contingent cues were previously extinguished. CONCLUSIONS: Acute MDMA can reinstate cocaine-seeking behaviour in mice.
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