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  • Title: Diffusion-weighted magnetic resonance imaging of head and neck squamous cell carcinomas.
    Author: Friedrich KM, Matzek W, Gentzsch S, Sulzbacher I, Czerny C, Herneth AM.
    Journal: Eur J Radiol; 2008 Dec; 68(3):493-8. PubMed ID: 19189427.
    Abstract:
    OBJECTIVE: To evaluate whether diffusion-weighted imaging (DWI) is a reliable technique to quantify microstructural differences between head and neck squamous cell carcinomas (SCC) and tumour-free soft tissue. MATERIALS AND METHODS: DWI was obtained from 20 patients with histologically proven, untreated head and neck SCC. DWI was acquired using a diffusion-weighted, navigated echo-planar imaging sequence with a maximum b-value of 800 s/mm2. For an objective assessment of image quality, the signal-to-noise ratio (SNR) was calculated. Microstructural differences between vital tumour tissue and tumour-free soft tissue were quantified by calculating the apparent-diffusion-coefficients (ADC) on a pixel by pixel method. RESULTS: Echo-planar DWI provided good image quality in all patients (mean SNR 18.4). The mean ADC of SCC, (0.64+/-0.28 x 10(-3) mm2/s), was significantly (P<0.0001) lower than that of the tumour-free soft tissue, (2.51+/-0.82 x 10(-3) mm2/s). CONCLUSION: DWI is a reliable diagnostic tool to quantify the microstructural differences between vital tumour tissue and tumour-free soft tissue in patients with head and neck SCC.
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