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  • Title: Zapotin prevents mouse skin tumorigenesis during the stages of initiation and promotion.
    Author: Cuendet M, Oteham CP, Maiti A, Craig BA, Cushman M, Moon RC, Pezzuto JM.
    Journal: Anticancer Res; 2008; 28(6A):3705-9. PubMed ID: 19189653.
    Abstract:
    BACKGROUND: Zapotin, a flavonoid associated with Casimiroa edulis, was isolated as part of a program to discover natural inhibitors of carcinogenesis. Zapote blanco, the fruit of Casimiroa edulis, is consumed in many parts of the world. Zapotin is a non-toxic inducer of cellular differentiation, apoptosis and cell cycle arrest with cultured HL-60 promyelocytic cells. MATERIALS AND METHODS: An efficient chemical synthesis for zapotin was devised. Using this synthetic material, activity was examined in the two-stage mouse skin carcinogenesis model. RESULTS: Topical zapotin significantly inhibited 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced mouse skin tumorigenesis, using the anti-initiation and anti-promotion protocols. CONCLUSION: Encouraging results from previous and current in vivo studies warrant further investigation of the chemopreventive activity of zapotin.
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